DHX30 is a replication stress-responsive R-loop helicase that safeguards genome stability
Elena R. Nedelcu, Nan Cher Yeo, Hannes Huber, Archana Bairavasundaram Prusty, Thinh Q. Truong, Nghi Doan-Phuong Dang, Soenke Harder, Johannes Lederbauer, Ivana Lessel, Nina Ripin, Christina Kiel, Utz Fischer, Hans‐Jürgen Kreienkamp, Davor Lessel
This study identifies DHX30 as an R-loop helicase that resolves RNA:DNA hybrids, prevents replication stress, and maintains genome stability in human and zebrafish cells.
bioRxiv · Oct 27, 2026 · PreprintMolecular Biology