Nghi Doan-Phuong Dang

This study identifies DHX30 as an R-loop helicase that resolves RNA:DNA hybrids, prevents replication stress, and maintains genome stability in human and zebrafish cells.

The paper shows senataxin and DNA-PKcs redundantly support NHEJ repair of RAG-induced DSBs during V(D)J recombination, with senataxin's function overlapping with RECQL5 and HLTF.

This study characterizes a zebrafish ebf3a mutant, revealing brain size reduction, functional impairments, and gene expression changes in sensory systems and the cerebellum.

This study identifies 25 individuals with DHX30 mutations, showing two clinical subtypes based on variant type and severity of developmental and neurological symptoms.