Author

Ivana Lessel

University of Regensburg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Davor LesseliD· 2 shared Andrea VenturaiD· 1 shared Archana Bairavasundaram PrustyiD· 1 shared Carol D. Morris· 1 shared Chiara Mastroleo· 1 shared Christina KieliD· 1 shared Davide PradellaiD· 1 shared Elena R. Nedelcu· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Davor LesselORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

DHX30 is a replication stress-responsive R-loop helicase that safeguards genome stability

Elena R. Nedelcu, Nan Cher Yeo, Hannes Huber, Archana Bairavasundaram Prusty, Thinh Q. Truong, Nghi Doan-Phuong Dang, Soenke Harder, Johannes Lederbauer, Ivana Lessel, Nina Ripin, Christina Kiel, Utz Fischer, Hans‐Jürgen Kreienkamp, Davor Lessel

This study identifies DHX30 as an R-loop helicase that resolves RNA:DNA hybrids, prevents replication stress, and maintains genome stability in human and zebrafish cells.

bioRxiv · Oct 27, 2026 · PreprintMolecular Biology

miRISC inhibition causes mitotic defects and synergizes with genotoxic agents in cancers

Minsi Zhang, Ziqi Jiao, Ylenia Cendon Florez, Ivana Lessel, Xiaoyi Li, Melissa A. Yao, Moritz Weigl, Mateusz M. Ozimek, Turgut Dogruluk, Kevin Chen, Keith Conrad Fernandez, Vinagolu K. Rajasekhar, Olesja Popow, João A. Paulo, Davide Pradella, , Gaspare La Rocca

The paper shows that inhibiting the HMWR complex causes mitotic defects and enhances cancer cell vulnerability when combined with genotoxic agents.

bioRxiv · Dec 15, 2025 · PreprintCancer Biology