Utz Fischer

DHX30 is a replication stress-responsive R-loop helicase that safeguards genome stability

This study identifies DHX30 as an R-loop helicase that resolves RNA:DNA hybrids, prevents replication stress, and maintains genome stability in human and zebrafish cells.

Molecular mechanism of coilin interaction with core snRNPs

The paper identifies the molecular mechanism by which coilin distinguishes mature from immature snRNPs through its C-terminus containing an RNA-binding region and a Tudor-like domain that interacts with Sm proteins.

Structure and flexibility of the DNA polymerase holoenzyme of vaccinia virus

The paper presents the 3.8 Å cryo-EM structure of the VACV DNA polymerase holoenzyme and shows its structural similarity to MPXV, with transient E9-D4 interactions and conformational flexibility.

U1 snRNP-dependent suppression of miRNA biogenesis by alternative intronic polyadenylation in melanoma

The paper shows that U1 snRNP-dependent intronic polyadenylation suppresses miRNA biogenesis in melanoma by altering TRPM1 alternative polyadenylation signals.

Genotype-phenotype correlations and novel molecular insights into the DHX30-associated neurodevelopmental disorders

This study identifies 25 individuals with DHX30 mutations, showing two clinical subtypes based on variant type and severity of developmental and neurological symptoms.