A Pooled Cell Painting CRISPR Screening Platform Enables de novo Inference of Gene Function by Self-supervised Deep Learning
Srinivasan Sivanandan, Bobby Leitmann, Eric Lubeck, Mohammad Muneeb Sultan, Panagiotis Stanitsas, Navpreet Ranu, Alexis Ewer, Jordan E. Mancuso, Zachary F. Phillips, Albert M. Kim, John W. Bisognano, John Cesarek, Fiorella Ruggiu, David Feldman, Daphne Koller, , Ci Chu
This paper introduces a pooled CRISPR screening platform combined with self-supervised deep learning to infer gene function from morphological phenotypes without target-specific biomarkers.
Nature Communications · Dec 16, 2025Peer-reviewedGenomics