Laminin switches terminal differentiation fate of human trophoblast stem cells under chemically defined culture conditions.
Victoria Karakis, Mahe Jabeen, John W. Britt, Abigail Cordiner, Adam Mischler, Feng Li, Adriana San‐Miguel, Balaji M. Rao
This paper establishes a chemically defined culture system for differentiating human trophoblast stem cells into extravillous trophoblast and syncytiotrophoblast lineages, showing that laminin-1 switches differentiation fate.
Journal of Biological Chemistry · Mar 25, 2023Peer-reviewedDevelopmental Biology