Promyelocytic leukemia (PML) suppresses hepatitis B virus cccDNA transcription through SUMOylation- and SMC5/6-dependent mechanisms
Jiapeng Wu, Feng Li, James Ahodantin, Masaya Funaki, Lishan Su
This study shows PML suppresses HBV cccDNA transcription via SUMOylation and SMC5/6-dependent mechanisms, with HBx modulating this interaction.
bioRxiv · Oct 9, 2026 · PreprintImmunology