Structural and Biochemical Studies of Dihydrofolate Reductase from Streptococcus pyogenes as a Target for Antifolate Antibiotics
Behnoush Hajian, Jolanta Krucinska, Michael Martins, Narendran G-Dayanan, Kishore Viswanathan, Sara Tavakoli, Dennis Wright
This study identifies potent DHFR inhibitors against S. pyogenes and determines its crystal structure to guide antifolate antibiotic development.
bioRxiv · Dec 21, 2018 · PreprintMicrobiology