Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype
Andriy O. Samokhin, Hyuk‐Soo Seo, Alison Leed…·Bradley A. Maron
This study develops a covalent peptide targeting NEDD9-SH3 to inhibit endothelial migration and fibroproliferative remodeling in PAH by stabilizing the RT loop and modulating sulfatase-1 activity.