Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of Familial Dysautonomia
Carrie E. Leonard, Jolie Quiros, Frances B. Lefcort, Lisa Anne Taneyhill
This study shows that loss of Elp1 in trigeminal ganglion neurons leads to impaired axon outgrowth, reduced target innervation, and decreased TrkA neuron survival, explaining facial pain and temperature sensation loss in Familial Dysautonomia.
eLife · Jun 17, 2022Peer-reviewedDevelopmental Biology