A high-throughput fluorescent indicator displacement assay and principal component/cluster data analysis for determination of ligand-nucleic acid structural selectivity
Rafael del Villar-Guerra, Robert D. Gray, John O. Trent, Jonathan B. Chaires
The paper introduces a high-throughput fluorescence indicator displacement assay combined with PCA and HCA to assess ligand selectivity for different DNA structures, showing selectivity for G4 structures in a subset of tested compounds.
bioRxiv · Sep 22, 2017 · PreprintBiophysics