Positive cooperativity enhances coupling of a second G protein to a GPCR dimer
Vaithish Velazhahan, Jamie Manning, Ning Ma, Henry Dalton Taylor, Sudati Shrestha, Qingchao Chen, Yue Ren, Stephen H McLaughlin, Adelaine Leung, Sukanta Bar, Maxwell Martin, Scott Blanchard, Wesley B. Asher, Joshua B Kelley, Henrik Dohlman, , Christopher G Tate
The paper shows that a second G protein couples with higher affinity to a GPCR dimer than the first, due to conformational stabilization by the first G protein.
bioRxiv · Nov 9, 2026 · PreprintBiochemistry