Positive cooperativity enhances coupling of a second G protein to a GPCR dimer
V. Velazhahan, J. Manning, N. Ma, H. D. Taylor, S. Shrestha, Q. Chen, Y. Ren, S. H. McLaughlin, A. Leung, S. Bar, M. Martin, S. Blanchard, W. B. Asher, J. B. Kelley, H. Dohlman, , Christopher G Tate
The paper shows that a second G protein couples with higher affinity to a GPCR dimer than the first, due to conformational stabilization by the first G protein.
bioRxiv · Nov 9, 2026 · PreprintBiochemistry