Yue Ren

The paper shows that a second G protein couples with higher affinity to a GPCR dimer than the first, due to conformational stabilization by the first G protein.

This paper presents computational methods for designing GPCR-binding miniproteins and validates them through high-throughput screening, producing agonists and antagonists for multiple GPCRs.

The paper introduces a quantitative method to measure and predict microbiome responses to antibiotics using a Microbiome Response Index (MiRIx) and applies it to human microbiome data.