The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages
Helena J. Barr, Sydney K. Caldwell, Justin M. Reimertz, Constanze Depp, Alec J. Walker, Samuel E. Marsh, Anushree S. Gupte, Maximilian Hingerl, Jasmin Patel, Sang-O Park, Sarah Ferraro, Jonathan Lipton, Beth Stevens
This study identifies brain border-associated macrophages (BAMs) as rhythmic cells regulated by the circadian clock, showing that their endocytic activity and amyloid-beta uptake are disrupted with age and in a mouse model of Alzheimer's disease.
bioRxiv · Dec 11, 2025 · PreprintNeuroscience