Alec J. Walker

This study identifies brain border-associated macrophages (BAMs) as rhythmic cells regulated by the circadian clock, showing that their endocytic activity and amyloid-beta uptake are disrupted with age and in a mouse model of Alzheimer's disease.

This study identifies the murine dura mater as a transient niche for early-postnatal B lymphopoiesis, highlighting the role of CXCL12-expressing fibroblasts in supporting B cell development.

The paper identifies a unique population of regulatory T cells in the murine meninges that maintain brain homeostasis by suppressing interferon-gamma-producing lymphocytes and preventing hippocampal damage.

The paper shows enzymatic dissociation causes gene expression changes in microglia and proposes a protocol to reduce these artifacts in scRNA-seq.

This study identifies nine distinct microglial states in mice across lifespan and after injury using single-cell RNA sequencing, revealing persistent and age-related changes.