Sex-Specific Induction of H3K27me1 in the Prefrontal Cortex Mediates the Enduring Effects of Early Life Stress
Jonathan Nguyen, Nidhi Byragoni, Nneka Arinzeh, Alessandro Bortolami, Simone Sidoli, Scott J. Russo, Eric J. Nestler, Angélica Torres‐Berrío
This study shows that early life stress causes sex-specific H3K27me1 accumulation in the prefrontal cortex, leading to long-term behavioral and cognitive effects in mice.
bioRxiv · Nov 25, 2025 · PreprintNeuroscience