Simone Sidoli

This study shows KAT6 and KAT7 maintain mitotic chromatin acetylation and composition, supporting postmitotic transcriptional memory and developmental competence in stem cells.

This study shows that NAD metabolism supports CTCF-cohesin chromatin regulation in EBV-transformed B-cells and identifies NAMPT inhibition as a potential therapeutic strategy.

This study shows EHMT1's functional rewiring during human cortical neurogenesis, revealing its shift from restraining pluripotency to supporting neuronal programs and its resilience to prolonged depletion.

This study investigates the metabolic and epigenetic changes in SDH-deficient cells and tumors, finding increased succinyl-CoA but no corresponding increase in histone succinylation or significant effects from desuccinylase inhibition.

This study shows that histone propionylation, influenced by nutrient availability, regulates T cell fate and antitumor immunity.

This study identifies amyloid fibrils in seminal fluid that bind and deliver RNA to sperm and the zygote during fertilization.

This study identifies a resistance mechanism in AML leukemic stem cells to PI3K inhibition and shows that combining PI3K and EZH1/2 inhibitors overcomes resistance.

This study identifies the Integrator complex as a key factor stabilizing NF-κB chromatin residence, essential for inflammatory gene activation in mouse and human cells.

The paper identifies a bimodal m6A code in cardiac development, showing how m6A stoichiometry and context regulate metabolic switches and gene expression.

This study identifies ribosomal proteins as major substrates of starvation-induced endosomal microautophagy in Drosophila, revealing its role in metabolic adaptation.

This study identifies H3K37me1 as a histone modification that regulates DNA replication origin selection by limiting MCM2-7 association with transcribed chromatin.

The paper identifies female-specific m6A RNA methylation changes in mouse livers under high-fat diet that correlate with post-transcriptional metabolic adaptations and protein remodeling.

The paper develops a structure prediction method using XL-MS data for disordered microsporidian proteins with no homologs, successfully modeling two spore wall proteins.

This study identifies histone succinylation as an inhibitor of JmjC demethylases, leading to stabilized repressive chromatin states and reduced transcription.

This study identifies the GNMT N-terminal tail and its phosphorylation at S9 as a regulatory mechanism linking folate feedback to SAM homeostasis.

This study identifies HIV-1-induced SUMOylation of host RNA splicing factors, mediated by Vif, which regulates viral RNA splicing and infectivity.

The paper shows that cleavage of histone H2A by Cathepsin L during ESC differentiation reduces nucleosome stability and counteracts gene activation.

This study uses scRNA-seq to analyze murine osteosarcoma models and identifies Skp2's role in metastasis, genomic instability, and immune activation, revealing potential therapeutic targets.

This study identifies SETD8 as a target of APC-coordinated GSK3 phosphorylation in colorectal cancer, showing that phosphorylation suppresses SETD8's oncogenic activity.

This study identifies dysregulated TGFβ-ERK signaling as a driver of aberrant extracellular matrix production in Noonan syndrome-associated pulmonary valve stenosis using iPSC models and patient tissue.

This paper develops a mass spectrometry-based method to profile single-cell histone post-translational modifications, demonstrating its ability to detect treatment responses and chromatin heterogeneity.

The paper shows that inhibiting the CoREST complex with corin alters RNA splicing, increases neoantigen expression, and enhances tumor immunity in melanoma.

This study shows that early life stress causes sex-specific H3K27me1 accumulation in the prefrontal cortex, leading to long-term behavioral and cognitive effects in mice.

The paper shows PRMT5 promotes chromatin escape of mRNAs by methylating SNRPB, affecting splicing and nuclear export.

This paper identifies EZH1-dependent H3K27me1 as an adaptive chromatin barrier limiting DNMT inhibitor response in colorectal cancer and shows that dual EZH1/2 inhibition synergizes with DNMTi to enhance therapeutic efficacy.

This study maps the Toxoplasma gondii interactome using crosslinking mass spectrometry and machine learning, identifying 405 PPIs with high confidence and validating their biological relevance.

The paper identifies semaphorin 3A as a secreted factor from revitalized MSCs that regulates HSPC proliferation in steady state and stress conditions.

This study shows PRMT5 sustains histone transcription and protein synthesis during S phase, maintaining genome integrity by regulating histone H4 methylation.

The paper identifies extracellular components in the developing fetal neocortex of humans and non-human primates using multi-omics approaches.

This paper combines MALDI-MSI and LC-MS/MS to map spatial protein changes in murine thymus during chemotherapy, identifying key proteins involved in regeneration and immune recovery.