Temporal single-cell profiling of the parabrachial Calca neurons reveals molecular dynamics driving nociplastic pain
Sekun Park, Hutchinson H Clarke, Feng Cao, Alexis Rose, Eunsoo Yang, Rachel R Felix, Jonathan Read, Jane Chen, Jordan L. Pauli, Richard D. Palmiter
The paper uses temporal single-cell RNA sequencing to study Calca neurons in mice and identifies BDNF as a key driver of persistent nociplastic pain.
bioRxiv · Aug 17, 2026 · PreprintNeuroscience