Richard D. Palmiter

This study shows that cholinergic input from the parabrachial nucleus to the central amygdala supports conditioned flavour avoidance learning by enabling long-timescale plasticity.

The paper shows that optogenetic activation of parabrachial tachykinin1 neurons can drive nonphotic circadian entrainment through a CeA molecular clock.

The paper uses temporal single-cell RNA sequencing to study Calca neurons in mice and identifies BDNF as a key driver of persistent nociplastic pain.

This study identifies parabrachial oxytocin receptor neurons as critical for linking social observation of distress to defensive behaviors in mice.

This paper identifies a population of Ntsr1-expressing neurons in the parabrachial nucleus that project to the ventromedial hypothalamus, modulating food intake and anxiety through chemogenetic activation and silencing.

The paper identifies a specific dopamine neuron population in mice required for anticipatory locomotion during food anticipation, showing genetic dissociation of behavioral components.

This study shows that gustatory thalamic neurons mediate aversive behaviors by responding to noxious stimuli and fear memory, with chemogenetic and optogenetic manipulation affecting aversive responses.

Single cell RNA sequencing reveals how adolescent sex hormones sculpt hypothalamic cell types required for mating behavior.

This paper develops a genetically encoded sensor, NOPLight, to detect endogenous N/OFQ release with high spatial and temporal resolution in vitro and in vivo.

This study shows that activation of parabrachial Calca neurons is necessary for chronic pain after nerve ligation and sufficient to drive nociplasticity in mice.

This study identifies Calca neurons in the parabrachial nucleus as mediators of second-order conditioning in mice through calcium imaging and chemogenetic inhibition.

The paper develops two genetically encoded tools to monitor and silence neuropeptide release in vivo, revealing neuropeptides, not glutamate, as the primary transmitter in Pavlovian threat learning.

The paper characterizes PBN neuron subclusters using single-cell RNA sequencing and maps their axonal projections, identifying 21 subclusters and two major ascending pathways.

The paper identifies CCK-expressing vestibular neurons as key drivers of motion-induced malaise and shows their role in inducing conditioned taste aversion through parabrachial nucleus activation.

The paper investigates how pubertal sex hormones regulate transcriptional changes in the medial preoptic area of mice during puberty, revealing sexually dimorphic gene regulatory networks.

This study shows PD-1 in hippocampal neurons regulates excitability, synaptic plasticity, and cognition, with anti-PD-1 improving cognitive function in mice and primates.

This study identifies PBLOprm1 neurons as critical for opioid-induced respiratory depression and shows their activation can rescue respiratory rhythms.

PIXEL-seq barcodes tissue sections with continuous polony clusters on a gel surface, reporting ≤1 µm resolution and >1,000 unique molecular identifiers per 10x10 µm2.

This study identifies GFRAL-expressing neurons in the hindbrain that suppress food intake through aversive pathways by responding to non-meal-related signals.

The paper shows that AgRP-neuron activation is required for cold-induced hyperphagia in mice.

The paper shows that male mice have nearly as many Kiss1RP3V neurons as females, which can stimulate testosterone synthesis when activated.

The paper investigates how parabrachial CGRP neurons control unconditioned responses and associative fear learning through distinct neural projections.

This study investigates the role of Kappa Opioid Receptor and dynorphin signaling in the central amygdala in regulating alcohol intake using genetic knockout models in mice.

This study shows that NKB signaling in the medial amygdala stimulates gonadotropin release in female mice independently of kisspeptin.