Sekun Park

This study shows that cholinergic input from the parabrachial nucleus to the central amygdala supports conditioned flavour avoidance learning by enabling long-timescale plasticity.

The paper shows that optogenetic activation of parabrachial tachykinin1 neurons can drive nonphotic circadian entrainment through a CeA molecular clock.

The paper uses temporal single-cell RNA sequencing to study Calca neurons in mice and identifies BDNF as a key driver of persistent nociplastic pain.

This paper identifies a population of Ntsr1-expressing neurons in the parabrachial nucleus that project to the ventromedial hypothalamus, modulating food intake and anxiety through chemogenetic activation and silencing.

This study shows that gustatory thalamic neurons mediate aversive behaviors by responding to noxious stimuli and fear memory, with chemogenetic and optogenetic manipulation affecting aversive responses.

This study shows that activation of parabrachial Calca neurons is necessary for chronic pain after nerve ligation and sufficient to drive nociplasticity in mice.

This study identifies Calca neurons in the parabrachial nucleus as mediators of second-order conditioning in mice through calcium imaging and chemogenetic inhibition.

The paper develops two genetically encoded tools to monitor and silence neuropeptide release in vivo, revealing neuropeptides, not glutamate, as the primary transmitter in Pavlovian threat learning.

The paper characterizes PBN neuron subclusters using single-cell RNA sequencing and maps their axonal projections, identifying 21 subclusters and two major ascending pathways.

The paper investigates how parabrachial CGRP neurons control unconditioned responses and associative fear learning through distinct neural projections.