A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels
Yucheng Xiao, Jonathan W. Theile, Agnes Zybura, Yanling Pan, Zhixin Lin, Theodore Cummins
This study identifies A-type FHFs as mediators of resurgent currents in TTX-resistant sodium channels, with FHF4A being critical for Nav1.8 and Nav1.9 channels, and shows its role in reducing neuronal excitability in nociceptive neurons.
eLife · Apr 20, 2022Peer-reviewedNeuroscience