Theodore Cummins

The paper establishes a zebrafish model to evaluate seizure activity caused by SCN2A and SCN8A variants and tests the efficacy of anti-seizure medications.

This study shows APOE4 reduces Kir4.1 expression and mitochondrial health in Müller cells, leading to retinal impairments, and MitoQ treatment restores these functions.

This paper identifies NaviPA1, a peptide that inhibits specific sodium channels in sensory neurons, reducing neuropathic pain in rats and human-derived neurons.

This study identifies A-type FHFs as mediators of resurgent currents in TTX-resistant sodium channels, with FHF4A being critical for Nav1.8 and Nav1.9 channels, and shows its role in reducing neuronal excitability in nociceptive neurons.

This study shows that hPSC-derived RGCs with the OPTN(E50K) mutation display neurodegenerative phenotypes, providing insights into glaucoma mechanisms.

This study investigates the effects of inhibiting specific voltage-gated sodium channel isoforms on epileptiform activity in mouse cortical slices, finding that Nav1.6 inhibition is more effective than Nav1.1 inhibition.

This study shows that astrocytes accelerate the functional maturation of retinal ganglion cells derived from human pluripotent stem cells in vitro.