Voluntary oxycodone self-administration produces analgesic tolerance and sex-dependent hyperalgesia across genetically diverse rats
Tolulope J. Ajanaku, Eamonn P. Duffy, Jonathon O. Ward, Luanne H. Hale, Caleb I Hodges, Laura M. Saba, Marissa A. Ehringer, Ryan K. Bachtell
This study shows that voluntary oxycodone self-administration in rats leads to analgesic tolerance and sex-dependent hyperalgesia, with genetic strain differences in thermal sensitivity and analgesic response.
bioRxiv · Aug 25, 2026 · PreprintAnimal Behavior & Cognition