Laura M. Saba

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

This study identifies strain-dependent genetic influences on oxycodone self-administration patterns in rats, revealing differences in acquisition, escalation, and burst-like responding.

This study shows that voluntary oxycodone self-administration in rats leads to analgesic tolerance and sex-dependent hyperalgesia, with genetic strain differences in thermal sensitivity and analgesic response.

RatXcan extends transcriptome-wide association studies to rats, enabling cross-species integration of GWAS and gene expression data to identify shared genetic mechanisms of complex traits.

This study quantifies protein expression in rat brains, identifies pQTLs, and links them to behavioral traits and human disorders.

This study identifies green tea compounds in plasma of mice with and without gut microbiomes, showing their metabolism is influenced by microbiome composition and diversity.

This study shows that sex and genetic background affect oxycodone self-administration in rats, with heritability estimates ranging from 0.25 to 0.54.

The paper identifies genetic factors influencing opsin expression and cell fate in Drosophila R7 photoreceptors through GWAS and transcriptome analysis.

The paper presents an improved rat reference genome, mRatBN7.2, which enhances genomic, transcriptomic, and proteomics data mapping and identifies millions of genetic variations across rat strains.

This paper introduces RCFGL, a fast method for joint estimation of condition-specific gene co-expression networks, showing improved computational efficiency and performance over existing methods.

The paper identifies cis-QTLs and eQTLs in HS rats across five brain regions, finds colocalization with human GWAS results, and shows higher eQTL density compared to human data.

The paper evaluates quantitative trait analysis methods for RNA expression in the HRDP to assess power and precision in identifying genetic variants associated with complex traits.

The paper identifies genes involved in R7 photoreceptor cell differentiation in Drosophila through genetic screens and analyzes their effects on Rh3 expression.

The paper assesses the association of two gene sets with smoking behaviors using GWAS data and finds they contribute little to the heritability of these traits.

The paper introduces CFGL, a method for inferring condition-specific gene co-expression networks, showing improved accuracy and revealing biological insights in rat and cancer datasets.