A BRRF1-CCR4-NOT axis underlies conserved transcriptome-wide loss of splicing fidelity during gammaherpesvirus reactivation
Trang T Nguyen, Anandita Ghosh, Nadeeshika Wickramarachchige-Dona, Tina M. O’Grady, Claire Roberts, Eman Y. Ishaq, Jordan Bass, Meggie Lam, Melody Baddoo, Nathan Ungerleider, Nick Van Otterloo, Jia Wang, Qian Zhang, Hong Liu, Yan Dong, , Erik K. Flemington
The paper identifies BRRF1 as a key driver of transcriptome-wide splicing defects during gammaherpesvirus reactivation by hijacking the CCR4-NOT complex.
bioRxiv · May 23, 2026 · PreprintPathology