Author

Tina M. O’Grady

University of LiègeORCID 0000-0002-1283-0293Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pathology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:multiome· 1

Frequent Co-Authors

DAVID EDWIN HILLiD· 2 shared Franck DequiedtiD· 2 shared Jean‐Claude TwizereiD· 2 shared Julien OlivetiD· 2 shared Marc VidaliD· 2 shared Michael A. CalderwoodiD· 2 shared Aaron D. Richardson· 1 shared Alejandro HochkoeppleriD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

DAVID EDWIN HILLORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A BRRF1-CCR4-NOT axis underlies conserved transcriptome-wide loss of splicing fidelity during gammaherpesvirus reactivation

Trang T Nguyen, Anandita Ghosh, Nadeeshika Wickramarachchige-Dona, Tina M. O’Grady, Claire Roberts, Eman Y. Ishaq, Jordan Bass, Meggie Lam, Melody Baddoo, Nathan Ungerleider, Nick Van Otterloo, Jia Wang, Qian Zhang, Hong Liu, Yan Dong, , Erik K. Flemington

The paper identifies BRRF1 as a key driver of transcriptome-wide splicing defects during gammaherpesvirus reactivation by hijacking the CCR4-NOT complex.

bioRxiv · May 23, 2026 · PreprintPathology

Expanding the HDAC druggable landscape beyond enzymatic activity

Julien Olivet, Soon Gang Choi, Salvador Sierra, Tina M. O’Grady, Mario de la Fuente Revenga, Florent Laval, Vladimir V. Botchkarev, Christoph Gorgulla, Paul W. Coote, Jérémy Blavier, Ezekiel A. Geffken, Jimit Lakhani, Kijun Song, Zoe C. Yeoh, Bin Hu, , Marc Vidal

This paper identifies a non-enzymatic HDAC inhibitor with anti-tumor and anti-psychedelic effects, showing reduced gene modulation compared to enzymatic inhibitors.

bioRxiv · Dec 7, 2022 · PreprintMolecular Biology

The viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape

Charlotte Vandermeulen, Tina M. O’Grady, Jérôme Wayet, Bartimée Galvan, Sibusiso B. Maseko, Majid Cherkaoui, Alice Desbuleux, Georges Coppin, Julien Olivet, Lamya Ben Ameur, Keisuke Kataoka, Seishi Ogawa, Olivier Hermine, Ambroise Marçais, Marc Thiry, , Jean‐Claude Twizere

This study shows that Tax and HBZ, viral oncoproteins, alter mRNA splicing in T-cells by interacting with spliceosome components, leading to changes in cancer-related genes.

PLoS Pathogens · Sep 20, 2021Peer-reviewedSystems Biology