Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator
Adrian L. Sanborn, Benjamin T. Yeh, Jordan T. Feigerle, Cynthia V. Hao, Raphael J.L. Townshend, Erez Lieberman Aiden, Ron O. Dror, Roger D. Kornberg
The paper identifies 150 transcriptional activation domains in yeast, shows their binding to Mediator, and develops a neural network to predict ADs across species.
eLife · Apr 27, 2021Peer-reviewedMolecular Biology