Discovery of high affinity and specificity stapled peptide Bcl-xL inhibitors using bacterial surface display
Marshall Case, Jordan Vinh, Anna Kopp, Matthew Smith, Greg M. Thurber
The paper develops high-affinity, specific stapled peptides that inhibit Bcl-xL, showing 10 nM affinity and 100-fold selectivity over other Bcl-2 family members.
bioRxiv · Dec 5, 2023 · PreprintSynthetic Biology