Elevations in plasma proinsulin predict the development of diabetes in NOD mice
Vriti Bhagat, Jorden Gill, Mélanie Lopes, C. Bruce Verchere
This study shows that elevated plasma proinsulin and PI:C ratios predict diabetes onset in NOD mice and correlate with reduced beta cell Pc1/3 expression.
bioRxiv · Jul 7, 2025 · PreprintCell Biology