C. Bruce Verchere

Transcriptional coactivator MED15 is required to maintain β-cell maturity

This study shows that MED15 is continuously required after weaning to maintain functional β-cell maturity in mice.

Human and mouse regenerative macrophages enhance beta cell survival, function, and proliferation

This study shows regenerative macrophages enhance beta cell survival, function, and proliferation in vitro through contact-independent mechanisms and promote a regenerative macrophage phenotype.

Islet amyloid disrupts MHC Class II antigen presentation and protects NOD mice from autoimmune diabetes.

This study shows that islet amyloid disrupts MHC Class II antigen presentation in islet macrophages, protecting NOD mice from autoimmune diabetes by reducing immune cell infiltration and antigen-specific T cell activation.

Elevations in plasma proinsulin predict the development of diabetes in NOD mice

This study shows that elevated plasma proinsulin and PI:C ratios predict diabetes onset in NOD mice and correlate with reduced beta cell Pc1/3 expression.

HumanIslets: An integrated platform for human islet data access and analysis

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction

This study shows that gut-derived bacterial flagellin contributes to beta-cell inflammation and dysfunction in type 2 diabetes.