Epigenetic Programming of Estrogen Receptor in Adipose Tissue by High Fat Diet Regulates Obesity-Induced Inflammation
Rui Juan Wu, Fen Fen Li, Shirong Wang, Jing Jia, Xin Cui, Yifei Huang, Xucheng Zhang, Jose A. Carrillo, Zufeng Ding, Jiuzhou Song, Liqing Yu, Huidong Shi, Bingzhong Xue, Hang Shi
This study shows that high fat diet induces DNA methylation at the Esr1 promoter in adipose tissue, reducing Esr1 expression and increasing inflammation, which can be reversed by targeting methylation.
bioRxiv · Jun 21, 2025 · PreprintPhysiology