Huidong Shi

This study identifies IL13 as a critical cytokine for the antitumor activity of polyfunctional CD4+ T cells modified with constitutively active Stat5, showing its role in enhancing immune responses and tumor control.

This paper identifies a TGF-β/S100A9/CXCR2 axis in metastatic TNBC that drives neutrophil expansion and immune suppression, with S100A9 loss enhancing immunotherapy response.

This study identifies IRF8 as a B cell-intrinsic regulator of antigen presentation that sustains CD8⁺ T cell antitumor immunity and predicts response to PD-1 blockade therapy.

This study identifies SOX6 as a key regulator of oligodendrocyte dysfunction under chronic stress, linking stress to myelination deficits through molecular mechanisms.

This study shows that PDE10A inhibition with ADT-030 suppresses tumor growth by disrupting MAPK signaling and enhancing antitumor immunity through immune cell modulation.

This study investigates the distinct and cooperative roles of host and tumor-derived Osteopontin in colorectal cancer liver metastasis using genetic knockout models and spatial transcriptomics.

This study shows indomethacin enhances chemo-immunotherapy in mice through both COX-dependent and independent mechanisms, including RAS inhibition.

This study examines how emtricitabine, an antiretroviral drug, alters DNA methylation and transcriptome patterns in skeletal muscle of HIV-infected mice, revealing potential mechanisms of ART-related muscle dysfunction.

This study shows that high fat diet induces DNA methylation at the Esr1 promoter in adipose tissue, reducing Esr1 expression and increasing inflammation, which can be reversed by targeting methylation.

The paper uses single-cell RNA sequencing to study myeloid cell repopulation after chemotherapy in mice, identifying a neutrophil-like monocyte subset with immunosuppressive and pro-tumor activities.

This study shows that CTU1 is essential for zebrafish development and erythroid differentiation, as its knockdown impairs larval development and blocks erythroid cell differentiation.

This study validates optical genome mapping (OGM) as a clinical tool for detecting structural variations in hematological neoplasms, showing high sensitivity and specificity compared to standard methods.