Liqing Yu

Epigenetic Programming of Estrogen Receptor in Adipose Tissue by High Fat Diet Regulates Obesity-Induced Inflammation

This study shows that high fat diet induces DNA methylation at the Esr1 promoter in adipose tissue, reducing Esr1 expression and increasing inflammation, which can be reversed by targeting methylation.

Hepatic fructose metabolism is antagonized by growth hormone/insulin-like growth factor signaling via regulation of ketohexokinase expression

This study identifies GH/IGF-1 signaling as a regulator of KHK expression, limiting fructose metabolism in the liver and contributing to MASLD.

Dysregulation of cholesterol and bile acid homeostasis in the gut-liver axis following Cryptosporidium intestinal infection

This study shows that Cryptosporidium infection disrupts bile acid and lipid homeostasis in the gut-liver axis, and bile supplementation reduces infection burden and restores intestinal epithelial function.