Jose Campos

Inferring the frequency spectrum of derived variants to quantify adaptive molecular evolution in protein-coding genes of Drosophila melanogaster

The paper develops a method to infer the site frequency spectrum (SFS) in Drosophila melanogaster to quantify adaptive molecular evolution, finding that ~50% of amino acid substitutions are positively selected but less than 0.5% of new mutations are beneficial.

Adaptive evolution is substantially impeded by Hill-Robertson interference in Drosophila

The paper quantifies how Hill-Robertson interference reduces adaptive evolution rates in Drosophila by ~27%, with effects varying by mutation rate.