Inferring the frequency spectrum of derived variants to quantify adaptive molecular evolution in protein-coding genes of Drosophila melanogaster
Peter D. Keightley, Jose Campos, Tom Booker, Brian Charlesworth
The paper develops a method to infer the site frequency spectrum (SFS) in Drosophila melanogaster to quantify adaptive molecular evolution, finding that ~50% of amino acid substitutions are positively selected but less than 0.5% of new mutations are beneficial.
bioRxiv · Feb 10, 2016Evolutionary Biology