Author

Brian Charlesworth

Primary ORCID profile (0000-0002-2706-355X · 9 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Brian CharlesworthiD9 papers · University of Edinburgh

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:DNA methylation· 1 Organism:Drosophila· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Jose Campos· 1 shared Lei Zhao· 1 shared Peter D. Keightley· 1 shared Tom Booker· 1 shared

Activity by Year

2016-2016 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 3 mutual co-author links

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1 shared paperEvolutionary Biology

Jose Campos

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2 papers

Recent·Most cited

Resolving the conflict between associative overdominance and background selection

Lei Zhao, Brian Charlesworth

The paper analyzes the conditions under which genetic variability at a neutral locus linked to a selected locus is retarded or accelerated, showing that background selection dominates when S is large, while associative overdominance can still occur with partially recessive mutations.

bioRxiv · Mar 4, 2016Evolutionary Biology

Inferring the frequency spectrum of derived variants to quantify adaptive molecular evolution in protein-coding genes of Drosophila melanogaster

Peter D. Keightley, Jose Campos, Tom Booker, Brian Charlesworth

The paper develops a method to infer the site frequency spectrum (SFS) in Drosophila melanogaster to quantify adaptive molecular evolution, finding that ~50% of amino acid substitutions are positively selected but less than 0.5% of new mutations are beneficial.

bioRxiv · Feb 10, 2016Evolutionary Biology