Jose Castro-Vildosola

Social stress causes gut dysbiosis in male, female, and aggressor mice

This study examines how chronic social defeat stress affects gut microbiome composition in male, female, and aggressor mice, finding stress-induced dysbiosis with sex-specific correlations.

Sphingosine-1-phosphate receptor 3 activation promotes sociability and regulates the expression of genes associated with anxiolytic-like behavior

This paper shows that S1PR3 agonists promote sociability and reduce anxiety-like behavior in mice by altering gene expression in the prefrontal cortex.

The glucocorticoid response element near the sphingosine-1-phopshate receptor 3 gene mitigates inflammatory processes and maladaptive behavior in females and stressed males

This study shows that GR-induced S1PR3 expression reduces social anxiety and stress-induced inflammation by affecting neural coherence in rats.