Paul Gueguen

This study identifies a keto-gluconeogenic metabolic axis that mirrors renal homeostasis and injury responses using spatial transcriptomics and biochemical analyses in AKI to CKD transition.

The paper identifies a pre-invasive malignant keratinocyte population in actinic keratosis, characterized by p63 and PITX1 regulation, and distinguishes early oncogenic programs from invasion effectors in squamous cell carcinoma.

This study identifies KLRG1 as a marker for cytotoxic CD4 T cells in cancer patients and shows their anti-tumor function and regulation by IL-6.

The paper identifies transcriptional shifts by analyzing missing data patterns in single-cell transcriptomes, revealing a metabolic shift in D. discoideum.

This study introduces STACAS v2, a semi-supervised method for integrating scRNA-seq data that outperforms existing methods by preserving biological variability using cell type annotations.