Sabina Müller

Sustained antigenic engagement programs multidimensional CTL states with distinct cytotoxic capacities

This study shows that sustained antigenic engagement leads to multidimensional remodeling and functional diversification of CTLs, maintaining cytotoxic activity while creating functionally distinct states.

Selective granzyme B replenishment dominates the molecular switch for sustained cytotoxicity in effector CD8+ T lymphocytes

This study shows that human CTLs sustain cytotoxicity by selectively replenishing granzyme B through de novo synthesis, maintaining its activity and supporting prolonged killing.

KLRG1 identifies circulating cytotoxic CD4 T cells with selective anti-tumor function in human cancer

This study identifies KLRG1 as a marker for cytotoxic CD4 T cells in cancer patients and shows their anti-tumor function and regulation by IL-6.

Stenocytosis: a mechanism for supramolecular attack particle transfer at the CTL lytic synapse

The paper describes stenocytosis, a mechanism by which CTLs transfer supramolecular attack particles into target cells through narrow actin gaps.

Perforin-mediated pore formation at the lytic synapse triggers the canonical pyroptotic cell death pathway

This study shows perforin triggers pyroptosis in target cells by activating the NLRP3/caspase-1/gasdermin D pathway, while sustained CTL interaction leads to apoptosis.