Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers
Xuehan Sun, Guillermo Eastman, Yu Shi, Subhi Saibaba, Ana K. Oliveira, John R. Lukens, Andrés Norambuena, Joseph A. Thompson, Michael D. Purdy, Kelly A. Dryden, Evelyn Pardo, James William Mandell, George S. Bloom
This study investigates how extracellular tau oligomers cause structural and functional damage to neuronal nuclei in tauopathies, showing increased invaginations and altered gene expression.
Alzheimer s & Dementia · Dec 9, 2023Peer-reviewedNeuroscience