Andrés Norambuena

The paper shows that mitochondrial NADK2-dependent NADPH synthesis mediates Tau oligomer uptake in neurons via LRP1, creating a cycle that exacerbates TauO toxicity.

The paper shows that mitochondrial response to nutrients is disrupted early in the cortex of APPSAA mice before symptoms appear, suggesting it as a presymptomatic event in Alzheimer's disease.

This study investigates how extracellular tau oligomers cause structural and functional damage to neuronal nuclei in tauopathies, showing increased invaginations and altered gene expression.

The paper identifies SOD1 as a mediator of lysosome-to-mitochondria communication and shows its dysregulation by amyloid-β oligomers in Alzheimer's disease.