Michael D. Purdy

The paper designs collagenous assemblies using a peptide self-assembly system and solves their structure with cryo-EM, revealing a non-twisting triple helix conformation that differs from the canonical right-handed triple helix.

This study investigates how extracellular tau oligomers cause structural and functional damage to neuronal nuclei in tauopathies, showing increased invaginations and altered gene expression.

This study identifies hibernating ribosomes tethered to mitochondria as an adaptive response to glucose depletion in fission yeast, showing their role in cell survival.

The paper determines the structure of the translating bacterial ribosome at 1.55 Å resolution using open access cryo-EM, enabling detailed analysis of ribosome polymorphism and drug design.