Author

James William Mandell

University of VirginiaORCID 0000-0002-5000-8276Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

George S. BloomiD· 2 shared Aizhen Xiao· 1 shared Alexis Petrosky· 1 shared Ana K. OliveiraiD· 1 shared Andrés NorambuenaiD· 1 shared Austin Hoggarth· 1 shared Benjamin W. PurowiD· 1 shared Binita RajbanshiiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

George S. BloomORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

S1PR3 mediates glial stimulated tumor invasion in response to interstitial fluid flow

R. Chase Cornelison, Samantha Howerton, Kinsley M. Tate, Caleb A. Stine, Alexis Petrosky, Kathryn M. Kingsmore, Sharon K. Michelhaugh, Jessica J. Cunningham, Katie Degen, Austin Hoggarth, Cora Esparza, Peng Jin, Maosen Wang, Caroline O’Brien, Aizhen Xiao, , Jennifer M. Munson

This study shows interstitial fluid flow upregulates S1PR3 in glial cells, promoting glioma invasion, and demonstrates that targeting S1PR3 can limit tumor progression.

bioRxiv · Dec 3, 2025 · PreprintCancer Biology

Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers

Xuehan Sun, Guillermo Eastman, Yu Shi, Subhi Saibaba, Ana K. Oliveira, John R. Lukens, Andrés Norambuena, Joseph A. Thompson, Michael D. Purdy, Kelly A. Dryden, Evelyn Pardo, James William Mandell, George S. Bloom

This study investigates how extracellular tau oligomers cause structural and functional damage to neuronal nuclei in tauopathies, showing increased invaginations and altered gene expression.

Alzheimer s & Dementia · Dec 9, 2023Peer-reviewedNeuroscience

Localization, induction, and cellular effects of tau-phospho-threonine 217

Binita Rajbanshi, James William Mandell, George S. Bloom

This study investigates the localization, induction, and cellular effects of tau-phospho-threonine 217 in brain and cultured neurons, finding increased levels in AD progression and reduced tau affinity for microtubules.

bioRxiv · Apr 18, 2022 · PreprintNeuroscience