Author

Joseph Ehlert

Northeastern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Albert-Ĺaszló BarabásiiD· 2 shared Jan VijgiD· 2 shared Xiao DongiD· 2 shared Alexander Y. MasloviD· 1 shared Bnaya GrossiD· 1 shared Bo JiniD· 1 shared Jan H.J. HoeijmakersiD· 1 shared Jonah SpectoriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersGenomics

Albert-Ĺaszló BarabásiORCID

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2 papers

Recent·Most cited

The aging genome exhibits organized vulnerability to somatic mutations

Joseph Ehlert, Ronald Cutler, Jonah Spector, Bnaya Gross, Orr Levy, Jan Vijg, Xiao Dong, Albert-Ĺaszló Barabási

This study identifies organized vulnerability in the aging genome, showing that certain genes and pathways are less mutated while others accumulate more mutations, suggesting a network-based mechanism for cellular decline.

bioRxiv · May 22, 2026 · PreprintGenomics

Negative Selection Allows DNA Mismatch Repair-Deficient Mouse Fibroblasts In Vitro to Tolerate High Levels of Somatic Mutations

Lei Zhang, Moonsook Lee, Xiaoxiao Hao, Joseph Ehlert, Zhongxuan Chi, Bo Jin, Alexander Y. Maslov, Albert-Ĺaszló Barabási, Jan H.J. Hoeijmakers, Winfried Edelmann, Jan Vijg, Xiao Dong

This study shows that DNA mismatch repair-deficient mouse fibroblasts can tolerate high mutation burdens in vitro without significant growth effects, revealing mutation-driven population changes and negative selection.

bioRxiv · May 4, 2024 · PreprintGenomics