Zhongxuan Chi

The paper studies how mutations in U2 snRNA affect splicing and gene expression, finding that U2-2 knockout phenocopies mutant effects and that splicing changes are influenced by both mutation and U2-2 levels.

This study shows that DNA mismatch repair-deficient mouse fibroblasts can tolerate high mutation burdens in vitro without significant growth effects, revealing mutation-driven population changes and negative selection.

This study uses single-cell whole-genome sequencing to analyze mutational landscapes in Msh2-deficient mouse fibroblasts, revealing elevated SNVs and INDELs with distinct mutational signatures.