Ronald R. Cutler

The paper uses integrated imaging and omics approaches to show that Actb and Arc mRNAs are packaged into distinct granules with different trafficking dynamics and functional roles.

The paper identifies female-specific m6A RNA methylation changes in mouse livers under high-fat diet that correlate with post-transcriptional metabolic adaptations and protein remodeling.

This study identifies organized vulnerability in the aging genome, showing that certain genes and pathways are less mutated while others accumulate more mutations, suggesting a network-based mechanism for cellular decline.

This paper develops a mass spectrometry-based method to profile single-cell histone post-translational modifications, demonstrating its ability to detect treatment responses and chromatin heterogeneity.

The paper identifies glypican-1 (GPC1) as a novel modulator of HIV-1 infection, showing its upregulation by a kinase inhibitor enhances viral infection through TGF-β signaling.

This study shows that CARM1 loss in GSCs disrupts developmental programming, shifts lineage towards radial glia, and creates a dependency on NGFR/NTRK signaling, making them vulnerable to NTRK inhibitors.

The paper identifies EXOSC4's interaction with a specific histone modification pair and shows its role in regulating non-coding transcription.

The paper shows that human fibroblasts undergo negative selection against harmful mutations, maintaining growth despite high mutation loads.

The paper uses a CRISPRi screen in hESC differentiation to identify enhancers with nonlinear regulatory activity, revealing a CTCF loop-constrained model for improved enhancer prediction.