Cryptochrome Loss Drives COPD-like Lung Pathology through Disrupted Alveolar Epithelial Proliferation and Immune Homeostasis
Tingting W. Mills, Chorong Han, Ji Ye Lim, Nobuya Koike, Sun Young Kim, Jaebok Wi, Hui Liu, Y Wang, Kazuhiro Yagita, Joseph L. Alcorn, Zheng Chen, Seung Hee Yoo
This study shows that loss of Cryptochrome 1 and 2 leads to COPD-like lung disease through disrupted epithelial proliferation and immune homeostasis, and that Nobiletin can alleviate these effects.
bioRxiv · May 21, 2026 · PreprintGenetics