Author

Seung Hee Yoo

The University of Texas Health Science Center at HoustonORCID 0000-0002-9930-560XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Biochemistry· 1 Bioinformatics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

Zheng CheniD· 5 shared Chorong Han· 3 shared Ji Ye Lim· 3 shared Sun Young KimiD· 3 shared Jaebok Wi· 2 shared Marvin WiriantoiD· 2 shared Sung Yun JungiD· 2 shared Tingting W. MillsiD· 2 shared

Activity by Year

2019-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersGenetics

Zheng ChenORCID

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Author profile →

5 papers

Recent·Most cited

FBXL21 regulates diurnal proteostasis and stress response by targeting DNAJB6 and client proteins

Ji Ye Lim, Jaebok Wi, Marvin Wirianto, Chorong Han, Sun Young Kim, Jane Nguyen, Sehyun Jung, Kristin L Eckel‐Mahan, Sung Yun Jung, Karyn Ann Esser, Zheng Chen, Seung Hee Yoo

This study identifies FBXL21 as a circadian E3 ligase that regulates proteostasis and stress response by targeting DNAJB6 and its client proteins, with implications for myopathies.

bioRxiv · May 22, 2026 · PreprintCell Biology

DHHC3-dependent S-Acylation of CRY1 regulates its subcellular localization and repressor function in the circadian clock

Ji Ye Lim, Shayahati Bieerkehazhi, Chorong Han, Sun Young Kim, Matthew L. Baker, Tingting W. Mills, Kuang‐Lei Tsai, Hyun Kyoung Lee, Sung Yun Jung, Zheng Chen, Askar M. Akimzhanov, Seung Hee Yoo

This study identifies S-acylation of CRY1 as a critical post-translational modification regulated by DHHC3, essential for its nuclear localization and repressor function in the circadian clock.

bioRxiv · May 22, 2026 · PreprintBiochemistry

Cryptochrome Loss Drives COPD-like Lung Pathology through Disrupted Alveolar Epithelial Proliferation and Immune Homeostasis

Tingting W. Mills, Chorong Han, Ji Ye Lim, Nobuya Koike, Sun Young Kim, Jaebok Wi, Hui Liu, Y Wang, Kazuhiro Yagita, Joseph L. Alcorn, Zheng Chen, Seung Hee Yoo

This study shows that loss of Cryptochrome 1 and 2 leads to COPD-like lung disease through disrupted epithelial proliferation and immune homeostasis, and that Nobiletin can alleviate these effects.

bioRxiv · May 21, 2026 · PreprintGenetics

A novel bioinformatics approach to reveal the role of circadian oscillations in AD development

Zhiwei Ji, Dazhi Shang, Pora Kim, Mengyuan Yang, Sijia Wu, Weiling Zhao, Eunju Kim, Marvin Wirianto, Zheng Chen, Seung Hee Yoo, Xiaobo Zhou

This study introduces ESOCVD, a computational platform to detect circadian gene expression patterns in AD using untimed transcriptome data, revealing five circadian alteration patterns in AD patients.

bioRxiv · Jul 16, 2020 · PreprintBioinformatics

Tissue-specific BMAL1 cistromes reveal that enhancer-enhancer interactions regulate rhythmic transcription

Joshua R Beytebiere, Alexandra J. Trott, Ben J. Greenwell, Collin A. Osborne, Hélène Vitet, Jessica Spence, Seung Hee Yoo, Zheng Chen, Joseph S. Takahashi, Noushin Ghaffari, Jérôme S. Menet

The paper shows BMAL1 DNA binding is tissue-specific and regulates rhythmic transcription through enhancer-enhancer interactions in the mouse liver.

Genes & Development · Mar 1, 2019Peer-reviewedGenetics