Author

Nobuya Koike

Kyoto Prefectural University of Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Kazuhiro YagitaiD· 3 shared Gen KondohiD· 2 shared Hitomi WatanabeiD· 2 shared Yasuhiro M. UmemuraiD· 2 shared Aarati Pokharel· 1 shared Akira Sugimoto· 1 shared Akiyo Kakibuchi· 1 shared Allison N. CastanedaiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersDevelopmental Biology

Kazuhiro YagitaORCID

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Author profile →

4 papers

Recent·Most cited

11β-HSD2 buffers fetal glucocorticoid exposure inducing Per1 expression under maternal stress

Kazuya Yabumoto, Yasuhiro M. Umemura, Hitomi Watanabe, Yasuhiro Endo, Nobuya Koike, Akiyo Kakibuchi, Akira Sugimoto, Taisuke Mori, Gen Kondoh, Kazuhiro Yagita

This study shows that 11β-HSD2 buffers maternal glucocorticoid surges during early development, preventing premature circadian clock activation and segmentation defects.

PNAS Nexus · Aug 24, 2026Peer-reviewedDevelopmental Biology

Cryptochrome Loss Drives COPD-like Lung Pathology through Disrupted Alveolar Epithelial Proliferation and Immune Homeostasis

Tingting W. Mills, Chorong Han, Ji Ye Lim, Nobuya Koike, Sun Young Kim, Jaebok Wi, Hui Liu, Y Wang, Kazuhiro Yagita, Joseph L. Alcorn, Zheng Chen, Seung Hee Yoo

This study shows that loss of Cryptochrome 1 and 2 leads to COPD-like lung disease through disrupted epithelial proliferation and immune homeostasis, and that Nobiletin can alleviate these effects.

bioRxiv · May 21, 2026 · PreprintGenetics

Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids

Yasuhiro M. Umemura, Nobuya Koike, Yoshiki Tsuchiya, Hitomi Watanabe, Gen Kondoh, Ryoichiro Kageyama, Kazuhiro Yagita

This study shows that CLOCK/BMAL1 disrupts the segmentation clock in mouse embryonic organoids by interfering with Hes7 oscillation and transcriptional regulation.

Proceedings of the National Academy of Sciences · Dec 20, 2021Peer-reviewedDevelopmental Biology

Natural Antisense Transcript of Period2, Per2AS, regulates the amplitude of the mouse circadian clock

Rebecca Mosig, Allison N. Castaneda, Jacob C. Deslauriers, Landon P. Frazier, Kevin L. He, Naseem Maghzian, Aarati Pokharel, Camille T. Schrier, Lily Zhu, Nobuya Koike, John J. Tyson, Carla B. Green, Joseph S. Takahashi, Shihoko Kojima

This study experimentally shows that Per2AS regulates circadian clock amplitude through a negative feedback loop with Per2, without producing a protein.

bioRxiv · Jul 27, 2020Molecular Biology